Thiago Batista

Thiago Batista is a Research Scientist II in the Claussnitzer Lab within the Type 2 Diabetes Systems Genomics Initiative (T2DSGi) at the Broad Institute of MIT and Harvard since 2021. His work aims at understanding gene regulatory mechanisms driving the formation of human adipocytes and how this process is impacted by genetic variation with emphasis on its role in the development of metabolic diseases such as type 2 diabetes, obesity, and other alterations of body fat distribution. He applies CRISPR-based genetic screens to perturb diverse coding and non-coding genomic regions of interest combined with high-dimensional readouts including gene expression profiling and chromatin accessibility at single-cell resolution, and high-content imaging.    Thiago has a master’s and Ph.D. in Physiology and Molecular Biology from the University of Campinas, Brazil. From 2015-2021, did his postdoctoral training in Cellular and Molecular Biology in Dr. C. Ronald Kahn’s lab at the Joslin Diabetes Center/Harvard Medical School where he studied regulation of gene expression by insulin, and developed human stem cell-derived myocyte models to identify novel intracellular signaling and gene expression mechanisms associated with insulin resistance and type 2 diabetes.